I am having problems with enlarged prostate. Will SAME have
any side effects that would affect my prostate? I am presently taking SAME and
my prostate is starting to act up. I don’t if it is related. Also should I be
taking certain amounts of Vitamin B and Folic acid with SAMe?
There are no known side effects of SAMe that would be related
to worsening of prostate symptoms that I have heard of. However, each person’s body is unique and has
the potential to generate different presentations of symptoms based on its
individual chemistry. For example, SAMe
can support certain detoxification reactions in the liver due to its nature as
a methyl donor. If you are taking
medication to control prostate symptoms there is a theoretical possibility that
the SAMe is causing your body to metabolize and it excrete it faster. This is more usually the case with nutrients
that specifically affect the cytochrome p450 systems of the liver like St.
John’s Wort and grapefruit. SAMe is not on this list and has never been
shown to affect medication metabolism but it is a theoretical possibility.
The other potential cause of how SAMe might be worsening
your prostate symptoms relates to the second part of your question. As you body metabolizes SAMe a byproduct
called homocysteine is produced.
Homocysteine is known to cause inflammation in the body and most
commonly associated with an elevated risk of heart disease. However, it is possible that it may cause
inflammation in other areas of your body.
To avoid this undesirable consequence of taking SAMe, it is advisable to
take plenty of vitamin B6, B12(preferably as methylcobalamin) and folic
acid. These nutrients support the mechanism
that the body uses to recycle homocysteine into its inactive counterpart.
SAMe is a very valuable supplement and I will reiterate the
point that it has never been shown to have any specific negative affects on the
prostate. However, the chance of increasing
homocysteine levels is real so I do advise a good B-complex supplement and
folic acid be taken along with SAMe.
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View More by Dr. Kevin Passero
Lead Medical Director
As a certified and fully trained Naturopathic Doctor, Passero has trained and preceptored with some of the nation's leading doctors in the field of natural medicine, working under the guidance of MD’s, Chiropractors, Naturopaths and Acupuncturists. Furthermore, he is currently the Vice President of the Maryland Association of Naturopathic Physicians.
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